BDBM276147 (R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-4-::US10071988, Example 374::US10071988, Example 54::US10233173, Example 374

SMILES C[C@@H](Oc1ncccn1)c1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1

InChI Key InChIKey=WGPIRIWUILWZNN-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276147   

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276147((R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]t...)
Affinity DataIC50: 11nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM276147((R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]t...)
Affinity DataIC50: 11nMAssay Description:Negative allosteric modulation of human GluN1A/GluN2B receptor expressed in T-REX-CHO cells preincubated for 5 mins followed by glutamate and glycine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276147((R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]t...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM276147((R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]t...)
Affinity DataKi:  67nMAssay Description:Displacement of 3-(3H) 1-(azetidin-1-yl)-2-(6- (4-fluoro-3-methyl-phenyl)pyrrolo-(3,2-6) pyridin-1yl)ethanone from GluN2B receptor in rat cortical me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276147((R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]t...)
Affinity DataIC50: 4.64E+3nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetRetinoic acid receptor RXR-alpha(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276147((R*)-2-[1-[1-[4-Chloro-3-(difluoromethoxy)phenyl]t...)
Affinity DataIC50: 4.64E+3nMpH: 7.4 T: 2°CAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent