BDBM276182 2-[[1-[3-(Difluoromethyl)phenyl]triazol-4-yl]methoxy]-5-methyl-pyrimidine;::US10071988, Example 89::US10233173, Example 89

SMILES Cc1cnc(OCc2cn(nn2)-c2cccc(c2)C(F)F)nc1

InChI Key InChIKey=OTZUCMMSLKQSFK-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 276182   

TargetRetinoic acid receptor RXR-alpha(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276182(2-[[1-[3-(Difluoromethyl)phenyl]triazol-4-yl]metho...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276182(2-[[1-[3-(Difluoromethyl)phenyl]triazol-4-yl]metho...)
Affinity DataIC50: 11nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM276182(2-[[1-[3-(Difluoromethyl)phenyl]triazol-4-yl]metho...)
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human GluN1A/GluN2B receptor expressed in T-REX-CHO cells preincubated for 5 mins followed by glutamate and glycine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM276182(2-[[1-[3-(Difluoromethyl)phenyl]triazol-4-yl]metho...)
Affinity DataKi:  65nMAssay Description:Displacement of 3-(3H) 1-(azetidin-1-yl)-2-(6- (4-fluoro-3-methyl-phenyl)pyrrolo-(3,2-6) pyridin-1yl)ethanone from GluN2B receptor in rat cortical me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM276182(2-[[1-[3-(Difluoromethyl)phenyl]triazol-4-yl]metho...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed