BDBM276943 US10072001, Example 119::US10259811, Example 119

SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ncnc2[nH]c(cc12)-c1cccc(Cn2ccnc2)c1

InChI Key InChIKey=HSLJCXAGEGDBAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276943   

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276943(US10072001, Example 119 | US10259811, Example 119)
Affinity DataIC50:  1.22nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276943(US10072001, Example 119 | US10259811, Example 119)
Affinity DataIC50:  1.23nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276943(US10072001, Example 119 | US10259811, Example 119)
Affinity DataIC50:  1.22nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276943(US10072001, Example 119 | US10259811, Example 119)
Affinity DataIC50:  1.23nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent