BDBM277063 US10072001, Example 255::US10259811, Example 255

SMILES N#Cc1cc(-c2ncnc3[nH]c(-c4ccc(C5CCN(CC(F)F)CC5)cc4)nc23)ccc1OC1CCN(C(=O)CO)CC1

InChI Key InChIKey=HXICXBITQYMWNF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 277063   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 277063BDBM277063(US10072001, Example 255 | US10259811, Example 255)
Affinity DataIC50: 1.53nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 277063BDBM277063(US10072001, Example 255 | US10259811, Example 255)
Affinity DataIC50: 1.53nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 277063BDBM277063(US10072001, Example 255 | US10259811, Example 255)
Affinity DataIC50: 3.48nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 277063BDBM277063(US10072001, Example 255 | US10259811, Example 255)
Affinity DataIC50: 3.48nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent