BDBM277324 US10072025, Example 2-2::tert-butyl 4-(3-(2-(4,4- difluoro-1- methylcyclohexyl)-1- oxoisoindolin-5-ylamino)- 4-oxo-4,5- dihydropyrazolo[4,3- c]pyridin-1-yl)-4- ethylpiperidine-1- carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc3C(=O)N(Cc3c2)C2(C)CCC(F)(F)CC2)c2c1cc[nH]c2=O

InChI Key InChIKey=AJYAJOWIKLAPEZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277324   

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 277324BDBM277324(US10072025, Example 2-2 | tert-butyl 4-(3-(2-(4,4-...)
Affinity DataIC50: 3.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 277324BDBM277324(US10072025, Example 2-2 | tert-butyl 4-(3-(2-(4,4-...)
Affinity DataIC50: 3.21nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent