BDBM277326 US10072025, Example 2-4::tert-butyl 4-ethyl-4-(3-(4- (1-methylpiperidin-4- yl)phenylamino)-4-oxo- 4,5-dihydropyrazolo[4,3- c]pyridin-1-yl) piperidine- 1-carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(cc2)C2CCN(C)CC2)c2c1cc[nH]c2=O

InChI Key InChIKey=QZZIQAPMORMEHV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277326   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277326(US10072025, Example 2-4 | tert-butyl 4-ethyl-4-(3-...)
Affinity DataIC50: 0.370nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277326(US10072025, Example 2-4 | tert-butyl 4-ethyl-4-(3-...)
Affinity DataIC50: 0.560nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent