BDBM277330 (5)-tert-butyl-4-ethyl-4-(3- (3-methyl-4-(2- methylmorpholine-4- carbonyl)phenylamino)-4- oxo-4,5- dihydropyrazolo[4,3- c]pyridin-1-yl) piperidine- 1-carboxylate::US10072025, Example 2-8

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(C(=O)N3CCO[C@@H](C)C3)c(C)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=MIXUUNJGYMRPJW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277330   

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277330(US10072025, Example 2-8 | (5)-tert-butyl-4-ethyl-4...)
Affinity DataIC50: 0.570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277330(US10072025, Example 2-8 | (5)-tert-butyl-4-ethyl-4...)
Affinity DataIC50: 0.620nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent