BDBM277332 (R or S)-tert-butyl 4-ethyl- 4-(4-oxo-3-((4-(2- (trifluoromethyl) azepan- 2-yl)phenyl) amino)-4,5- dihydro-1H-pyrazolo[4,3- c] pyridin-1-yl) piperidine- 1-carboxylate::US10072025, Example 2-10

SMILES CCC1(n2nc(Nc3ccc([C@@]4(C(F)(F)F)CCCCCN4)cc3)c3c(=O)[nH]ccc32)CCN(C(=O)OC(C)(C)C)CC1

InChI Key InChIKey=PWYKXEFCCILMII-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277332   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 277332BDBM277332(US10072025, Example 2-10 | (R or S)-tert-butyl 4-e...)
Affinity DataIC50: 13.9nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 277332BDBM277332(US10072025, Example 2-10 | (R or S)-tert-butyl 4-e...)
Affinity DataIC50: 16.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent