BDBM277366 4-((1-(1-(tert- butoxycarbonyl)-4- ethylpiperidin-4-yl)-4-oxo- 4,5-dihydro-1H-pyrazolo [4,3-c] pyridin-3- yl)amino)-2- methylbenzoic acid::US10072025, Example 2-44

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(C(O)=O)c(C)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=QYHXGVWXCTYPJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277366   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277366(US10072025, Example 2-44 | 4-((1-(1-(tert- butoxyc...)
Affinity DataIC50: 0.230nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277366(US10072025, Example 2-44 | 4-((1-(1-(tert- butoxyc...)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent