BDBM277438 US10072026, Example 1-32::US10947254, Example 1-32::US11780852, Example 1-32

SMILES COC(=O)CN1[C@H]5CCC[C@@H]1C[C@@H](Nc3nc(Nc2cc(C)[nH]n2)cc4ncccc34)C5

InChI Key InChIKey=ABHCRSDHBNSQKV-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 277438   

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277438BDBM277438(US10072026, Example 1-32 | US10947254, Example 1-3...)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277438BDBM277438(US10072026, Example 1-32 | US10947254, Example 1-3...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277438BDBM277438(US10072026, Example 1-32 | US10947254, Example 1-3...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277438BDBM277438(US10072026, Example 1-32 | US10947254, Example 1-3...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent