BDBM277443 US10072026, Example 1-37::US10947254, Example 1-37::US11780852, Example 1-37

SMILES Cc5cc(Nc4cc1ncccc1c(N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(N)=O)n4)n[nH]5

InChI Key InChIKey=ZKRWFROFEZHDEB-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 277443   

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277443BDBM277443(US10072026, Example 1-37 | US10947254, Example 1-3...)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277443BDBM277443(US10072026, Example 1-37 | US10947254, Example 1-3...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277443BDBM277443(US10072026, Example 1-37 | US10947254, Example 1-3...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277443BDBM277443(US10072026, Example 1-37 | US10947254, Example 1-3...)
Affinity DataKi:  50.5nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent