BDBM277929 2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile::US10040781, Example 151::US10253019, Example 151

SMILES OCC(=O)N1CCC(Oc2ccc(cc2C#N)-c2ncnc(Nc3ccc(cc3)N3CCN(CC3)C3COC3)n2)C(F)(F)C1

InChI Key InChIKey=RBTZIYDJVWQOAH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 277929   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277929(2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl...)
Affinity DataIC50:  1.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM277929(2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl...)
Affinity DataIC50:  1.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277929(2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl...)
Affinity DataIC50:  122nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277929(2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl...)
Affinity DataIC50:  1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM277929(2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl...)
Affinity DataIC50:  1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277929(2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-4-yl...)
Affinity DataIC50:  1.22E+5nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent