BDBM277942 (S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile::US10040781, Example 164::US10253019, Example 164

SMILES FC1(F)CN(CC[C@@H]1Oc1ccc(cc1C#N)-c1ncnc(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1)C(=O)c1ccn[nH]1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 277942   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277942((S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)pip...)
Affinity DataIC50:  3.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM277942((S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)pip...)
Affinity DataIC50:  1.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277942((S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)pip...)
Affinity DataIC50:  155nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277942((S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)pip...)
Affinity DataIC50:  3nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM277942((S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)pip...)
Affinity DataIC50:  1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277942((S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)pip...)
Affinity DataIC50:  1.55E+5nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent