BDBM27879 4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydropyridin-2-one::BMS-536924::CHEMBL401930::US10710978, Compound BMS536924
SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1
InChI Key InChIKey=ZWVZORIKUNOTCS-OAQYLSRUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 27879
Affinity DataIC50: 100nMpH: 7.0 T: 30°CAssay Description:The IGF-1 receptor tyrosine kinase was assayed using the synthetic polymer poly(Glu/Tyr) as a phosphoacceptor substrate. Incorporated radioactivity w...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory concentration against IGF-1R kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:In vitro inhibitory concentration against IR kinase with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP3A4-BzRes in vitro by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 153nMAssay Description:Inhibition of NH2-terminal glutathione S-transferase fused human recombinant IGF-IR catalytic domain expressed in insect cells using poly(Glu:Tyr) su...More data for this Ligand-Target Pair
Affinity DataIC50: 1.71E+4nMAssay Description:In vitro inhibitory concentration against HER2 with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibitory concentration EGF receptor with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:In vitro inhibitory concentration against MEK with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP2D6 in vitro by 50%; b = not determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP2C19 in vitro by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibitory concentration against VEGFR2 with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 4.87E+3nMAssay Description:In vitro inhibitory concentration against Met with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 341nMAssay Description:In vitro inhibitory concentration against LCK with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP1A2 in vitro by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:In vitro inhibitory concentration against FAK with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:In vitro inhibitory concentration against IGF-1R Sal kinase with ATP concentration at 1/2KmMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP3A4-BFC in vitro by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP2C9 in vitro by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of IGF1R expressed in SAL cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of IGF1R in mouse SAL cells assessed as thymidine incorporationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP3A4 after 20 mins by BFC fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP3A4 assessed as dealkylation of 7-benzyloxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 7.4 T: 37°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a dealkylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Befo...More data for this Ligand-Target Pair