BDBM278872 N-(2-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 51

SMILES Brc1sccc1NC(=O)c1csc2ncc(nc12)N1CCCNCC1

InChI Key InChIKey=AIVLTKKOYTXLJN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278872   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278872BDBM278872(N-(2-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)th...)
Affinity DataIC50: 1.16E+3nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent