BDBM278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9

SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=IGZQEXMDAKABFO-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 278979   

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.490nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.490nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.490nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.490nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.490nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.490nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 2.60nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278979BDBM278979(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 17nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent