BDBM279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165

SMILES CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=UXTFTMXAFOTATJ-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 279134   

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 73nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 73nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 73nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 73nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 73nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 73nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 110nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent