BDBM279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197

SMILES CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1

InChI Key InChIKey=GRFJYHDUOKDAKO-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279166   

LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  190nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50:  13nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent