BDBM280368 2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[3-(pyrrolidine-1-carbonyl)pyridin-4-yl]pyridin-4-amine::US10030004, Compound 34::US10501436, Compound 34::US11053216, Compound 34::US11702401, Compound 34

SMILES CC(=C)c1cnc(cc1Nc1ccncc1C(=O)N1CCCC1)-c1cc(Cl)ccc1F

InChI Key InChIKey=FHRZBVSUXBSDPP-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280368   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  149nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  77.3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  149nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  77.3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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antibodypediaGoogleScholar

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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  149nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  77.3nMMore data for this Ligand-Target Pair

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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  149nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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In DepthDetails US Patent

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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50:  77.3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280368(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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