BDBM281949 N-[(S)-(1-(3,4-Difluoro- phenyl)-ethyl]-2-({5- [4-(oxetan-3-ylamino)- quinazolin-6-yl]- thiophen-2-ylmethyl}- amino)-nicotinamide::US10030016, Example 4.35

SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(NC3COC3)c2c1)c1ccc(F)c(F)c1

InChI Key InChIKey=ZWDSPJCRZPEWDT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281949   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 281949BDBM281949(N-[(S)-(1-(3,4-Difluoro- phenyl)-ethyl]-2-({5- [4-...)
Affinity DataIC50: 100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent