BDBM282421 2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) benzylamino)-N-(3- methoxyphenyl)-5- (trifluoromethyl)nicotinamide::US10030016, Example 301

SMILES COc1cccc(NC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]nc(N)c3c2)C(F)(F)F)c1

InChI Key InChIKey=IIPPARZKWKDLJC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 282421   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM282421(2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) ben...)
Affinity DataIC50: 100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent