BDBM282761 5-(3-cyano-5-fluoro-phenoxy)-2,2-difluoro-3- hydroxy-3-methyl-1,1-dioxo-benzothiophene- 4-carbonitrile::US9884843, Compound 105

SMILES CC1(O)c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C#N)S(=O)(=O)C1(F)F

InChI Key InChIKey=POSXHXCSTBQADM-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282761   

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM282761(US9884843, Compound 105 | 5-(3-cyano-5-fluoro-phen...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM282761(US9884843, Compound 105 | 5-(3-cyano-5-fluoro-phen...)
Affinity DataEC50:  48nMAssay Description:About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent