BDBM283397 N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3-chloro-8-cyanoquinolin-6- yl)methyl)isonicotinamide::US10023557, Example 49::US10308637, Example 49::US11021463, Example 49::US9611252, Example 49

SMILES N#Cc1cc(Cc2cc(C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccn2)cc2cc(Cl)cnc12

InChI Key InChIKey=GDWMEKXUNIOULX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 283397   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 283397BDBM283397(US10023557, Example 49 | N-((3-chloro-6-fluoro-1H-...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lifesci Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 283397BDBM283397(US10023557, Example 49 | N-((3-chloro-6-fluoro-1H-...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 283397BDBM283397(US10023557, Example 49 | N-((3-chloro-6-fluoro-1H-...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 283397BDBM283397(US10023557, Example 49 | N-((3-chloro-6-fluoro-1H-...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent