BDBM283743 6 N-[4-[(3-fluoroazetidin-3-yl)methyl]phenyl]-6-methoxy-2-(trifluoromethyl)pyrimidine-4-carboxamide::US10023559, Example 68

SMILES COc1cc(nc(n1)C(F)(F)F)C(=O)Nc1ccc(CC2(F)CNC2)cc1

InChI Key InChIKey=MCWMTCYOFHHKHB-UHFFFAOYSA-N

Data  1 KI  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283743   

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM283743(6 N-[4-[(3-fluoroazetidin-3-yl)methyl]phenyl]-6-me...)
Affinity DataKi:  7.10nMpH: 7.4Assay Description:HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM283743(6 N-[4-[(3-fluoroazetidin-3-yl)methyl]phenyl]-6-me...)
Affinity DatapH: 7.4Assay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent