BDBM283983 4-(6-(4-(2-(2- fluorophenyl)-2- hydroxyacetyl)piperazin- 1-yl)pyridin-3-yl)- 6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10023570, Example 10::US10174027, Example 10
SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C(O)c2ccccc2F)c2c(cnn2c1)C#N
InChI Key InChIKey=AEVHNUITSFVPFS-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 283983
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...More data for this Ligand-Target Pair