BDBM284551 1-(5-(3-cyano-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridin- 4-yl)pyridin-2-yl)-N-(2- hydroxyethoxy)piperidine- 4-carboxamide::US10023570, Example 566::US10174027, Example 566

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NOCCO)c2c(cnn2c1)C#N

InChI Key InChIKey=KDJHUKIWRFTHII-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284551   

LigandChemical structure of BindingDB Monomer ID 284551BDBM284551(US10023570, Example 566 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284551BDBM284551(US10023570, Example 566 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 9nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 284551BDBM284551(US10023570, Example 566 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 9nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 284551BDBM284551(US10023570, Example 566 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 35.9nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 284551BDBM284551(US10023570, Example 566 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 35.9nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 284551BDBM284551(US10023570, Example 566 | 1-(5-(3-cyano-6-(1- meth...)
Affinity DataIC50: 35.9nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent