BDBM28469 (2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaene-5-}sulfonamido)-3-methylbutanoic acid::dibenzofuran (DBF) scaffold, (S)-14

SMILES COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O

InChI Key InChIKey=MKAIHDAGQJQAHA-KRWDZBQOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 28469   

TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  2nMpH: 7.5 T: 22°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  120nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed