BDBM28560 4-(4-fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),3,7,10-pentaen-8-amine::thiazole-based tricyclic inhibitor, 32a

SMILES CNc1nc2sc(nc2c2n(C)cnc12)-c1ccc(F)cc1

InChI Key InChIKey=MCWGUGKKHNUTER-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28560   

LigandPNGBDBM28560(4-(4-fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-...)
Affinity DataIC50:  26nMpH: 7.5 T: 22°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM28560(4-(4-fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM28560(4-(4-fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-...)
Affinity DataIC50:  3.10E+3nMT: 25°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed