BDBM285822 (6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 4::US9796680, Example 4

SMILES O[C@@H]1CNC2(CC2)[C@H](C(F)F)[C@H]1O

InChI Key InChIKey=HNWFXDPDLGNHIM-SRQIZXRXSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285822   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285822((6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octan...)
Affinity DataKi:  8nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285822((6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octan...)
Affinity DataKi:  8nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285822((6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octan...)
Affinity DataIC50:  6.5nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285822((6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octan...)
Affinity DataIC50:  6.5nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent