BDBM286290 5-amino-3-(7-ethoxyquinolin-3- yl)-1-(2-hydroxyethyl)-1H- pyrazole-4-carboxamide MS (ESI) (M + H)+ = 342.4::US9518026, Example 83::US9956214, Compound 1577

SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CCO)c(N)c1C(N)=O

InChI Key InChIKey=QCAIXILBXUUYFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286290   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286290(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(2-hydroxyeth...)
Affinity DataIC50:  10nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286290(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(2-hydroxyeth...)
Affinity DataIC50:  89nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286290(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(2-hydroxyeth...)
Affinity DataIC50:  181nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetUncharacterized protein(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM286290(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(2-hydroxyeth...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent