BDBM286321 N-(5,6-dimethoxy-1H-benzo[d]imidazol-2-yl)-3-((6-oxo-3-(pyridin-3-yl)pyridazin-1(6H)-yl)methyl)benzamide::US9567320, Example 15

SMILES COc1cc2nc(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccnc4)c3)[nH]c2cc1OC

InChI Key InChIKey=XRAMVXDDZUODTO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286321   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286321(N-(5,6-dimethoxy-1H-benzo[d]imidazol-2-yl)-3-((6-o...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286321(N-(5,6-dimethoxy-1H-benzo[d]imidazol-2-yl)-3-((6-o...)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
US Patent