BDBM286482 2-Methoxy-6-(6-methoxy-4-((2-phenylpyrimidin-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole::US9518064, Example 101

SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccccc3)cc(OC)cc2o1

InChI Key InChIKey=UNPQYHPCORNOFB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286482   

TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286482(2-Methoxy-6-(6-methoxy-4-((2-phenylpyrimidin-4-yl)...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286482(2-Methoxy-6-(6-methoxy-4-((2-phenylpyrimidin-4-yl)...)
Affinity DataIC50:  0.920nMT: 2°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent