BDBM287614 N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(7-methylpyrrolo[1,2-f][1,2,4]triazin-2-ylamino)phenyl)acrylamide::US10085983, Compound J-9

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc2ccc(C)n2n1

InChI Key InChIKey=ZGIBAXLVHBLNHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287614   

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287614(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  105nMT: 25°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287614(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  16nMT: 25°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent