BDBM28806 5-methyl-N-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine::triazolopyrimidine-based compound, DSM93

SMILES Cc1cc(Nc2ccccc2C)n2ncnc2n1

InChI Key InChIKey=IBFDNTZQRMCCCF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28806   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei (strain Anka))
University of Washington At Seattle

LigandPNGBDBM28806(5-methyl-N-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]...)
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington At Seattle

LigandPNGBDBM28806(5-methyl-N-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]...)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM28806(5-methyl-N-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]...)
Affinity DataKd:  2.50E+5nMAssay Description:Binding affinity to SARS-CoV2 PLpro (71 to 314 residues) expressed in Escherichia coli BL21(DE3) by SOFAST-HMQC titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed