BDBM288260 5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-methyl-::US10087185, Example 78

SMILES Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F

InChI Key InChIKey=RGSHYTRIWVSUFU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288260   

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288260(5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-...)
Affinity DataIC50:  0.126nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent