BDBM288308 US10087188, Example 1::US10087188, Example 6

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCC[C@@H](C1)C(O)=O

InChI Key InChIKey=RXTBDWMAPHSRCE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 288308   

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of 6-His-tagged recombinant full length BTK (unknown origin) expressed in baculovirus-transfected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 0.510nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 7.20nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 98nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
LigandPNGBDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed