BDBM288355 (1S,3R)-3-[8- amino-1-(2- fluoro-4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl} phenyl)imidazo [1,5-a]pyrazin-3- yl]cyclohexane- carboxylic acid::US10087188, Example 10

SMILES Nc1nccn2c(nc(-c3ccc(cc3F)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCC[C@@H](C1)C(O)=O

InChI Key InChIKey=VSZGIHXMKQGEBL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288355   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288355((1S,3R)-3-[8- amino-1-(2- fluoro-4-{[4- (trifluoro...)
Affinity DataIC50: 0.390nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent