BDBM288561 4-(8-amino-1-{4-[(4- cyclopropylpyridin-2- yl)carbamoyl]phenyl} imidazo[1,5-a]pyrazin- 3- yl)bicyclo[2.2.2] octane-1-carboxylic acid::US10087188, Example 169

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C3CC3)c12)C12CCC(CC1)(CC2)C(O)=O

InChI Key InChIKey=ACCFFAKVNQYGRK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288561   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288561(4-(8-amino-1-{4-[(4- cyclopropylpyridin-2- yl)carb...)
Affinity DataIC50: 0.190nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent