BDBM289074 1-{1-[5-Chloro-4-fluoro-2- methoxy-3-(1-methylazetidin-3- yl)phenyl]ethyl}-3- (difluoromethyl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine2::US10092570, Example 75::US10376513, Example 75::US10646492, Example 75::US11433071, Example 75::US9730939, Example 75

SMILES COc1c(cc(Cl)c(F)c1C1CN(C)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12

InChI Key InChIKey=VSAZWRHMIUNBII-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 289074   

LigandPNGBDBM289074(1-{1-[5-Chloro-4-fluoro-2- methoxy-3-(1-methylazet...)
Affinity DataIC50: <10nMpH: 6.7 T: 25°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM289074(1-{1-[5-Chloro-4-fluoro-2- methoxy-3-(1-methylazet...)
Affinity DataIC50: <10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM289074(1-{1-[5-Chloro-4-fluoro-2- methoxy-3-(1-methylazet...)
Affinity DataIC50: <10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM289074(1-{1-[5-Chloro-4-fluoro-2- methoxy-3-(1-methylazet...)
Affinity DataIC50: <10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM289074(1-{1-[5-Chloro-4-fluoro-2- methoxy-3-(1-methylazet...)
Affinity DataIC50: <10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent