BDBM290069 US9573961, Example 54

SMILES Cc1c(ccc(F)c1C#N)[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1cc(F)c(cc1F)-n1cnnn1

InChI Key InChIKey=WCCOWCLGPBQKND-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290069   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM290069(US9573961, Example 54)
Affinity DataIC50: 100nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent