BDBM290226 US9573958, Compound 21

SMILES CN(C)C(C)(C)C=C(C#N)C(=O)N1CCCC(n2c(=NC(=O)c3ccc(-c4cn[nH]c4)s3)[nH]c3ccccc32)C1

InChI Key InChIKey=KCTHPFHTRDQXRF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290226   

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 290226BDBM290226(US9573958, Compound 21)
Affinity DataIC50: 3nMpH: 7.5Assay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent