BDBM292345 N-(2-(diethylamino)ethyl)-2-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 1

SMILES CCN(CC)CCNC(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1

InChI Key InChIKey=KSXZIQVIDPCSIU-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 292345   

LigandPNGBDBM292345(US10100058, Example 1 | N-(2-(diethylamino)ethyl)-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length His-tagged CaMK2delta expressed in baculovirus using Biotin labelled STK1 as substrate after 1 hr in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM292345(US10100058, Example 1 | N-(2-(diethylamino)ethyl)-...)
Affinity DataIC50: 1.62nMAssay Description:The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM292345(US10100058, Example 1 | N-(2-(diethylamino)ethyl)-...)
Affinity DataEC50:  17.1nMAssay Description:CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM292345(US10100058, Example 1 | N-(2-(diethylamino)ethyl)-...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed