BDBM292351 (S)-N-(azetidin-2-ylmethyl)-2-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 7

SMILES O=C(NC[C@@H]1CCN1)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1

InChI Key InChIKey=PKHHGNKLUXIADM-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292351   

LigandPNGBDBM292351(US10100058, Example 7 | (S)-N-(azetidin-2-ylmethyl...)
Affinity DataIC50: 6.05nMAssay Description:The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM292351(US10100058, Example 7 | (S)-N-(azetidin-2-ylmethyl...)
Affinity DataEC50:  132nMAssay Description:CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent