BDBM292354 (S)-N-((2-propylpyrrolidin-2-yl)methyl)-2-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 10

SMILES CCC[C@@]1(CNC(=O)c2ccnc(c2)-c2cnn3ccc(nc23)-c2cccs2)CCCN1

InChI Key InChIKey=JTFPYEIIXXUWEI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292354   

LigandPNGBDBM292354(US10100058, Example 10 | (S)-N-((2-propylpyrrolidi...)
Affinity DataIC50: 9.80nMAssay Description:The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM292354(US10100058, Example 10 | (S)-N-((2-propylpyrrolidi...)
Affinity DataEC50:  99.2nMAssay Description:CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent