BDBM292712 8-Chloro-1-(2,5-dichlorophenyl)-3-methyl-1H-pyrazolo[4,3-c][1,5]naphthyridin-4(5H)-one::US10105349, Example 19::US10543194, Example 19

SMILES Cc1nn(-c2cc(Cl)ccc2Cl)c2c1c(=O)[nH]c1ccc(Cl)nc21

InChI Key InChIKey=JPAMGWGKKSMUIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292712   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292712(US10105349, Example 19 | 8-Chloro-1-(2,5-dichlorop...)
Affinity DataIC50: 73nMAssay Description:r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292712(US10105349, Example 19 | 8-Chloro-1-(2,5-dichlorop...)
Affinity DataIC50: 73nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent