BDBM292942 US10105367, Example 228::US10376514, Example 228

SMILES COc1ccc(Cn2c3ncc(CN4CCC5(CCOCC5)N4C)cc3c3ncnn3c2=O)cc1

InChI Key InChIKey=DRPGXSKMJNNINK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292942   

LigandPNGBDBM292942(US10105367, Example 228 | US10376514, Example 228)
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
US Patent

LigandPNGBDBM292942(US10105367, Example 228 | US10376514, Example 228)
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent