BDBM292986 6-(4-Methoxybenzyl)-9-(2,2,2-trifluoro-1-morpholinoethyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one::US10105367, Example 272::US10376514, Example 272

SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(N2CCOCC2)C(F)(F)F)cc1

InChI Key InChIKey=QGSHILNYLICGPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292986   

LigandPNGBDBM292986(6-(4-Methoxybenzyl)-9-(2,2,2-trifluoro-1-morpholin...)
Affinity DataIC50: <100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM292986(6-(4-Methoxybenzyl)-9-(2,2,2-trifluoro-1-morpholin...)
Affinity DataIC50: <100nMT: 25°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent