BDBM293975 (2S)-4-(4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-3-methylphenoxy)- 2-methylbutan-2-ol::US10106553, Compound 7

SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1

InChI Key InChIKey=VSTUWRQZHQVVOB-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 293975   

LigandPNGBDBM293975(US10106553, Compound 7 | (2S)-4-(4-(5-((4-(1-(1H- ...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM293975(US10106553, Compound 7 | (2S)-4-(4-(5-((4-(1-(1H- ...)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM293975(US10106553, Compound 7 | (2S)-4-(4-(5-((4-(1-(1H- ...)
Affinity DataEC50:  170nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent