BDBM295055 3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]-N-(3-hydroxy-propyl)-4-methyl-benzenesulfonamide::US10112926, Example 9

SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCCO

InChI Key InChIKey=ZHHKIDAEQSNMOI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 295055   

LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50:  300nMpH: 7.5 T: 25°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50: >9.10E+3nMpH: 7.5 T: 25°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50:  890nMpH: 7.5 T: 25°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50:  5.90E+3nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50:  14nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50:  220nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM295055(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Affinity DataIC50:  1.92E+3nMpH: 7.5 T: 25°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent