BDBM295086 (S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulfonyl)-2- methylphenyl)-3-(3- methylisoxazol-5- yl)pyridin-2-amine acetic acid salt::US10112926, Example 19.22

SMILES CN(C)[C@H]1CCN(C1)S(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1cc(C)no1

InChI Key InChIKey=VLIFRAXBRLFKDB-KRWDZBQOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 295086   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295086((S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulf...)
Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295086((S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulf...)
Affinity DataIC50:  5.80E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295086((S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulf...)
Affinity DataIC50:  1.40E+3nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295086((S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulf...)
Affinity DataIC50:  8.60E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295086((S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulf...)
Affinity DataIC50:  510nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295086((S)-5-(5-((3- (dimethylamino)pyrrolidin- 1-yl)sulf...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent